Formulation And In Vitro Evaluation Of Sumatriptan Succinate Oral Thin Films
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چکیده
منابع مشابه
Preparation and in vivo evaluation of oral dissolving films containing sumatriptan succinate
The present investigation deals with the formulation of oral dissolving films (ODFs) of sumatriptan succinate which is used for the treatment of migraine. Rapidly dissolving films have acquired great importance in present scenario because of exclusive properties. The films of sumatriptan succinate were carried out using different grades of HPMC E3, E6, and E15, maltodextrin DE6, xanthan gum and...
متن کاملFabrication and characterisation of lavender oil - plant phospholipid based Sumatriptan succinate hybrid solid lipid nanoparticles.
Background: Nanostructured lipid carriers (NLCs) of sumatriptan succinate (SS) were prepared by using lavender oil. In ancient days, lavender oil was used for the treatment of a migraine. The natural anti-migraine agent, lavender oil, combined with an anti-migraine drug such as SS in a nano-formulation, will be a practical alternative approach in migraine therapy. Objective: NLCs of sumatri...
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UNLABELLED BACK GROUND AND THE PURPOSE OF STUDY: Sumatriptan succinate is a Serotonin 5- HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first-pass metabolism, resulting in a low absolute bioavailability of about 15%. The aim of this work was to design mucoadhesive bilayered buccal tablets of sumatriptan succinate to ...
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Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...
متن کاملFreeze-dried k-carrageenan/chitosan polyelectrolyte complex-based insert: a novel intranasal delivery system for sumatriptan succinate
Intranasal route, ensuring suitable bioavailability of medicines under circumvention of the gastrointestinal degradation and hepatic first-pass elimination, has been a popular choice for drug delivery. Among nasal dosage forms, mucoadhesive solid inserts have been shown to resist mucociliary clearance and provide a prolonged nasal residence time. Hence, the purpose of this study was the prepara...
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